Hanson Super Precision Vessel Improves Testing Results

In USP Apparatus 2 the quality of the dissolution vessel is known to be a significant factor impacting the accuracy and repeatability of test results. But what exactly do we mean by quality, and what can be done about it? Teledyne Hanson Research addresses this subject in detail in a new report based on data from six years of testing in the field, working with vessels manufactured to different levels of precision, as installed in Hanson testers.

The gains in performance for what we have termed the super-precision vessel (Hanson SPV) are showing up consistently in a significantly reduced coefficient of variation and a far greater ability to pass the USP PVT at Stage 1. Further, recent improvements in manufacturing methods and economies of scale have brought the cost of the Hanson SPV much closer to that of the standard-precision vessel. Based on the long-term success of the SPV in the SR8-Plus™, Teledyne Hanson is now making this product available for the Vision G2™ series of testers as well.

In this 20-page report entitled “Improving the Consistency of USP Apparatus 2 with Hanson Research Super Precision Vessels,” Teledyne Hanson sheds new light on geometric irregularities within the hemisphere and their impact on vessel-to-vessel dissolution rates, and discusses related subjects including:

  • An overview of instrument-related perturbation factors and how the vessel fits in.
  • Test results from six years of PVTs conducted in the field on Hanson units with standard-precision versus super-precision vessels installed.
  • Test results from six years of PVTs conducted in the field on Hanson units with standard-precision versus super-precision vessels installed.
  • Detailed views of the critical inner surface of the hemisphere through X-ray CT scanning.
  • Color mapping of the vessel’s conformance to—and/or deviation from—an ideal geometry.
  • The origin and evolution of calibrator tablets and how the introduction of geometric mean and %CV criteria into the USP PVT has increased the need for super-precision vessels.
  • Summary of key findings of prior investigators exploring the inextricable relationship between vessel geometry, hydrodynamics, and dissolution rates.
  • Glass vessel manufacturing methods and recent improvements in quality and cost.
  • Preventing product out-of-specification (OOS) and instrument out-of-calibration (OOC) results and the headaches that come with them.
  • Preventing product out-of-specification (OOS) and instrument out-of-calibration (OOC) results and the headaches that come with them.
  • Indicators for knowing when or when not to up-grade to the Hanson SPV.
  • Benefits of super-precision vessels in applications beyond chemical calibration.

To receive your free copy of the complete report, contact Teledyne Hanson Research and request Apparatus Performance Report 99-390-005.