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Pharmaceutical Lab Testing Technology

Category: Dissolution

Dilution at Multiple Time Points

January 19, 2022

Dilution at Multiple Time Points

On Hanson's programmable dissolution testers, the Dilution at Multiple Time Points event allows the user to perform multiple dilutions during the test. When using this event, a programmed dilution occurs after each sample point. Unlike a typical single dilution at the end of a test, this event can be used as a switch that turns on and off as needed...

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Pausing the Spindle Rotation During a Test

January 19, 2022

Pausing the Spindle Rotation During a Test

Programming the Pause event on Hanson's dissolution testers will stop the spindle/paddle rotation temporarily during a test. This is a useful feature that allows for a complete vessel change, pH change with media addition, other types of media modification, or for any other reason. A good example is when working with an enteric coated dosage form, ...

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Change Dissolution Test Parameters Automatically During a Test

February 1, 2021

Change Dissolution Test Parameters Automatically During a Test

When developing methods for dissolution testing of solid dosage forms, identifying the optimum set of parameters can be difficult and time-consuming. Variables such as bath temperature and paddle speed have a significant impact on API release rates and on the ability to create a consistently repeatable method that will pass the scrutiny of regulato...

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Magazine Travel for Optimum Sampling Position

January 29, 2021

Magazine Travel for Optimum Sampling Position

The Magazine Travel event on Hanson dissolution testers allows precise settings for the positioning of the basket and paddle shafts, crucial for compendial compliance. The event moves the magazine with its sampling probes to control the sample height within the vessel, allowing the tester to stay in compliance when media loss occurs. For non-replen...

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Teledyne Hanson Dissolution Testers for Assessment of Amoxicillin Tablets

January 29, 2021

Teledyne Hanson Dissolution Testers for Assessment of Amoxicillin Tablets

In a recently published study conducted in Pakistan, Teledyne Hanson's dissolution testers were used to assess differences in release of the active pharmaceutical ingredient (API) co-amoxiclav from finished solid dosage formulations, comparing the innovator to generic tablets. API release was determined with dissolution testing and HPLC analysis. T...

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